Brewers vs. Cardinals Predictions & Picks: Odds, Moneyline, Spread - September 21

Thursday's game that pits the Milwaukee Brewers (86-66) against the St. Louis Cardinals (67-85) at Busch Stadium should be a competitive matchup based on our computer prediction, which projects a final score of 6-4 in favor of the Brewers. First pitch is at 1:15 PM ET on September 21.

The Cardinals will call on Miles Mikolas (7-12) versus the Brewers and Wade Miley (8-4).

Brewers vs. Cardinals Game Info & Odds

• When: Thursday, September 21, 2023 at 1:15 PM ET
• Where: Busch Stadium in St. Louis, Missouri
• How to Watch on TV: MLB Network
• Live Stream: Watch this game on Fubo!

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Brewers vs. Cardinals Score Prediction

Our pick for this game is Brewers 6, Cardinals 5.

Total Prediction for Brewers vs. Cardinals

• Total Prediction: Over 8.5 runs

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Discover More About This Game

• Brewers Injury Report

• Cardinals vs Brewers Betting Trends & Stats

• Cardinals vs Brewers Pitching Matchup

• Cardinals vs Brewers Odds

• How to Watch Cardinals vs Brewers

Brewers Performance Insights

• The Brewers are underdogs for the first time in a while, as they have not been listed as underdogs in their last 10 games.
• When it comes to the over/under, Milwaukee and its foes are 4-6-0 in its previous 10 contests.
• The Brewers have not covered a spread in any of their past 10 games (one of those contests had a spread).
• The Brewers have been victorious in 35, or 51.5%, of the 68 contests they have been chosen as underdogs in this season.
• This season, Milwaukee has come away with a win 30 times in 59 chances when named as an underdog of at least -105 or worse on the moneyline.
• The moneyline set for this matchup implies the Brewers have a 51.2% chance of coming away with a victory in the contest.
• Averaging 4.5 runs per game (680 total), Milwaukee is the 18th-highest scoring team in baseball.
• The Brewers have pitched to a 3.78 ERA this season, which ranks third in baseball.

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Brewers Schedule